InterPro domain: IPR006984

General Information

  • Identifier IPR006984
  • Description rRNA-processing protein Fcf1/Utp23
  • Number of genes 300
  • Gene duplication stats Loading...
  • Associated GO terms GO:0032040  

Abstract

Utp23 share homology with PINc domain protein Fcf1. They are components of the small subunit processome (SSU) that are involved in rRNA-processing and ribosome biogenesis [ 1 , 2 ].

Depletion of yeast Fcf1 and Fcf2 leads to a decrease in synthesis of the 18S rRNA and results in a deficit in 40S ribosomal subunits [ 3 ].


1. Fcf1p and Fcf2p are novel nucleolar Saccharomyces cerevisiae proteins involved in pre-rRNA processing. Biochem. Biophys. Res. Commun. 346, 546-54
2. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Proc. Natl. Acad. Sci. U.S.A. 103, 9464-9

Species distribution

Gene table