InterPro domain: IPR006958

In budding yeasts, Mak16 forms part of the 66S pre-ribosomal particles and functions as a transacting actor involved in rRNA processing [ 1 , 2 ]. The Schistosoma mansoni (Blood fluke) Mak16 has been shown to target protein transport to the nucleolus [ 3 ].

1. Yeast virus propagation depends critically on free 60S ribosomal subunit concentration. Mol. Cell. Biol. 15, 2772-81
2. Mak16p is required for the maturation of 25S and 5.8S rRNAs in the yeast Saccharomyces cerevisiae. Yeast 23, 495-506
3. SmMAK16, the Schistosoma mansoni homologue of MAK16 from yeast, targets protein transport to the nucleolus. Mol. Biochem. Parasitol. 108, 225-36