InterPro domain: IPR006953
General Information
- Identifier IPR006953
- Description Vesicle tethering protein Uso1/P115-like , head domain
- Number of genes 144
- Gene duplication stats Loading...
- Associated GO terms GO:0005737 GO:0000139 GO:0006886 GO:0048280
Abstract
This domain identifies a group of proteins, which are described as: General vesicular transport factor, Transcytosis associated protein (TAP) or Vesicle docking protein, this myosin-shaped molecule consists of an N-terminal globular head region, a coiled-coil tail which mediates dimerisation, and a short C-terminal acidic region [ 1 ]. p115 tethers COP1 vesicles to the Golgi by binding the coiled coil proteins giantin (on the vesicles) and GM130 (on the Golgi), via its C-terminal acidic region. It is required for intercisternal transport in the Golgi stack. This domain is found in the head region. The head region is highly conserved, but its function is unknown. It does not seem to be essential for vesicle tethering [ 2 ]. The N-terminal part of the head region contains context-detected Armadillo/beta-catenin-like repeats.
1. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. J. Cell Biol. 157, 45-62