InterPro domain: IPR006939
General Information
- Identifier IPR006939
- Description SNF5/SMARCB1/INI1
- Number of genes 123
- Gene duplication stats Loading...
- Associated GO terms GO:0006338 GO:0000228
Abstract
SNF5 is a component of the yeast SWI/SNF complex, which is an ATP-dependent nucleosome-remodelling complex that regulates the transcription of a subset of yeast genes. SNF5 is a key component of all SWI/SNF-class complexes characterised so far [ 1 ]. This family consists of the conserved region of SNF5, including a direct repeat motif. SNF5 is essential for the assembly promoter targeting and chromatin remodelling activity of the SWI-SNF complex [ 2 ]. SNF5 is also known as SMARCB1, for SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily b, member 1, and also INI1 for integrase interactor 1. Loss-of function mutations in SNF5 are thought to contribute to oncogenesis in malignant rhabdoid tumours (MRTs) [ 3 ].
1. Identification and analysis of the Arabidopsis thaliana BSH gene, a member of the SNF5 gene family. Nucleic Acids Res. 27, 2393-9
2. Essential roles of Snf5p in Snf-Swi chromatin remodeling in vivo. Mol. Cell. Biol. 21, 4311-20
3. Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer. Nature 394, 203-6