InterPro domain: IPR006849

Elongator complex protein 1 (also known as Iki3) is a component of the RNA polymerase II elongator complex, which is a major histone acetyltransferase component of the RNA polymerase II (RNAPII) holoenzyme. The eukaryotic elongator complex has been associated with many cellular activities, including transcriptional elongation [ 1 , 2 ], but its main function is tRNA modification [ 3 , 4 ]. It is required for the formation of 5-methoxy-carbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) groups on uridine nucleosides present at the wobble position of many tRNAs [ 5 ].

1. Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. Mol. Cell 3, 109-18
2. Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol. Cell. Biol. 21, 8203-12
3. An early step in wobble uridine tRNA modification requires the Elongator complex. RNA 11, 424-36
4. A coordinated codon-dependent regulation of translation by Elongator. Cell Cycle 11, 4524-9
5. Elongator: transcriptional or translational regulator? Transcription 3, 273-6