InterPro domain: IPR006840

General Information

  • Identifier IPR006840
  • Description Glutathione-specific gamma-glutamylcyclotransferase
  • Number of genes 305
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003839   GO:0006751  

Abstract

The ChaC family of proteins function as gamma-glutamyl cyclotransferases acting specifically to degrade glutathione but not other gamma-glutamyl peptides [ 1 , 2 ]. It is is conversed across all phyla and represents a new pathway for glutathione degradation in living cells.


1. Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione. EMBO Rep. 13, 1095-101
2. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Biochem. J. 468, 73-85

Species distribution

Gene table