InterPro domain: IPR006811
General Information
- Identifier IPR006811
- Description RNA polymerase II subunit A
- Number of genes 142
- Gene duplication stats Loading...
- Associated GO terms GO:0004721 GO:0005634 GO:0006397
Abstract
The highly conserved and essential protein Ssu72 has intrinsic phosphatase activity and plays an essential role in the transcription cycle. Ssu72 was originally identified in a yeast genetic screen as enhancer of a defect caused by a mutation in the transcription initiation factor TFIIB [ 1 ]. It binds to TFIIB and is also involved in mRNA elongation. Ssu72 is further involved in both poly(A) dependent and independent termination. It is a subunit of the yeast cleavage and polyadenylation factor (CPF), which is part of the machinery for mRNA 3'-end formation. Ssu72 is also essential for transcription termination of snRNAs [ 2 ].
1. Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. EMBO J. 22, 1588-98
2. A role for SSU72 in balancing RNA polymerase II transcription elongation and termination. Mol. Cell 10, 1139-50