InterPro domain: IPR006691

General Information

  • Identifier IPR006691
  • Description DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat

Abstract

This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure [ 1 ]. This region has been shown to bind DNA non-specifically and may stabilise the DNA-topoisomerase complex [ 2 ].


1. C-terminal domain of gyrase A is predicted to have a beta-propeller structure. Proteins 47, 258-64
2. DNA gyrase: structure and function. Crit. Rev. Biochem. Mol. Biol. 26, 335-75

Species distribution

Gene table