InterPro domain: IPR006634

General Information

  • Identifier IPR006634
  • Description TRAM/LAG1/CLN8 homology domain
  • Number of genes 1266
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016021  

Abstract

TLC is a protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1pare essential for acyl-CoA-dependent ceramide synthesis [ 1 ], TRAM is a subunitof the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possessmultiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additionalhomeobox domains [ 2 ].


1. Lag1p and Lac1p are essential for the Acyl-CoA-dependent ceramide synthase reaction in Saccharomyces cerevisae. Mol. Biol. Cell 12, 3417-27
2. Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human. Genome Res. 8, 1259-72

Species distribution

Gene table