InterPro domain: IPR006633

The CASH domain is shared by many carbohydrate-binding proteins and sugar hydrolases. The CASH domain is characterised by internal repetitions of glycines and hydrophobicresidues that correspond to the repetitive units of a predicted or observed right-handed beta-helix structure of the pectate lyase superfamily. The basic structural unit ofthis family consists of three beta-strands that form a single turn of the beta-helix. Each turn contains ~20 amino acids, and is normally repeated between 7 and 11 times toform the elongated helix structure. The repeats show a low degree of sequence identity when compared with each other. The region of homology withthe CASH domain corresponds to the core region of the beta-helix, covering from the second to the sixth repeat [ 1 ].

1. CASH--a beta-helix domain widespread among carbohydrate-binding proteins. Trends Biochem. Sci. 27, 59-62