InterPro domain: IPR006597

General Information

  • Identifier IPR006597
  • Description Sel1-like repeat
  • Number of genes 763
  • Gene duplication stats Loading...

Abstract

Sel1-like repeats are tetratricopeptide repeat sequences originally identified in a Caenorhabditis elegans receptor molecule which is a key negative regulator of the Notch pathway [ 1 ]. Mammalian homologues have since been identified although these mainly pancreatic proteins have yet to have a function assigned.


1. The Caenorhabditis elegans sel-1 gene, a negative regulator of lin-12 and glp-1, encodes a predicted extracellular protein. Genetics 143, 237-47

Species distribution

Gene table