InterPro domain: IPR006594

The 33-residue LIS1 homology (LisH) motif is found in eukaryotic intracellular proteins involved in microtubule dynamics, cell migration, nucleokinesis and chromosome segregation. The LisH motif is likely to possess a conserved protein-binding function and it has been proposed that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly. The LisH motif is found associated to other domains, such as WD-40, SPRY, Kelch, AAA ATPase, RasGEF, or HEAT[ 1 , 2 , 3 , 4 ].

The secondary structure of the LisH domain is predicted to be two alpha- helices [ 5 ].

1. A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration. Hum. Mol. Genet. 10, 2813-20
2. Characterization of a Drosophila melanogaster orthologue of muskelin. Gene 297, 69-78
3. A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM. Gene 303, 47-54
4. The structure of Sif2p, a WD repeat protein functioning in the SET3 corepressor complex. J. Mol. Biol. 351, 923-35