InterPro domain: IPR006558

This LamG-like jellyroll fold domain is found in the metalloproteinase Pappalysin-1 [ 1 ] and Usherin [ 2 ]. Its function is unknown.

1. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module. J. Biol. Chem. 282, 10988-99
2. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc. Natl. Acad. Sci. U.S.A. 104, 4413-8