InterPro domain: IPR006539

P-ATPases (also known as E1-E2 ATPases) ([intenz:3.6.3.-]) are found in bacteria and in a number of eukaryotic plasma membranes and organelles [ 1 ]. P-ATPases function to transport a variety of different compounds, including ions and phospholipids, across a membrane using ATP hydrolysis for energy. There are many different classes of P-ATPases, which transport specific types of ion: H ⁺ , Na ⁺ , K ⁺ , Mg ²⁺ , Ca ²⁺ , Ag ⁺ and Ag ²⁺ , Zn ²⁺ , Co ²⁺ , Pb ²⁺ , Ni ²⁺ , Cd ²⁺ , Cu ⁺ and Cu ²⁺ . P-ATPases can be composed of one or two polypeptides, and can usually assume two main conformations called E1 and E2.

Type IV ATPases have been shown to be involved in the transport of phospholipids [ 2 , 2 ], being involved in signal transduction, cell division, and vesicular transport. These ATPases are found in eukaryotes.

1. Evolution of substrate specificities in the P-type ATPase superfamily. J. Mol. Evol. 46, 84-101
2. Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs. J Biol Chem 294, 1794-1806