InterPro domain: IPR006369

This entry represents protoheme IX farnesyltransferase, also known as haem O synthase, an enzyme that creates an intermediate in the biosynthesis of haem A [ 1 ]. This enzyme converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor.

1. Assignment and functional roles of the cyoABCDE gene products required for the Escherichia coli bo-type quinol oxidase. J. Biochem. 122, 415-21