InterPro domain: IPR006329

General Information

  • Identifier IPR006329
  • Description AMP deaminase
  • Number of genes 300
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003876   GO:0032264  

Abstract

AMP-deaminase (AMPD) is a large, well-conserved eukaryotic protein that catalyzes the hydrolytic deamination of adensosine monophosphate (AMP) to inosine monophosphate (IMP), and so plays an important role in purine metabolism. In mammalian liver, the reaction catalysed by AMP-deaminase constitutes a rate-limiting step in adenine nucleotide catabolism [ 1 ].

Not all members of the family are active enzymes: YBR284W and YJL070C lack residues for binding the catalytic zinc ion, and YJL070C lacks substrate binding residues.


1. Expression patterns of AMP-deaminase isozymes in human hepatocellular carcinoma (HCC). Mol. Cell. Biochem.

Species distribution

Gene table