InterPro domain: IPR006269

General Information

  • Identifier IPR006269
  • Description 3-deoxy-8-phosphooctulonate synthase
  • Number of genes 164
  • Gene duplication stats Loading...
  • Associated GO terms GO:0005737   GO:0008676  

Abstract

These sequences describe 2-dehydro-3-deoxyphosphooctonate aldolase. Alternate names include 3-deoxy-d-manno-octulosonic acid 8-phosphate and KDO-8 phosphate synthetase. It catalyzes the aldol condensation of phosphoenolpyruvate with D-arabinose 5-phosphate.

phosphoenolpyruvate + D-arabinose 5-phosphate + H 2 O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate

In Gram-negative bacteria, this is the first step in the biosynthesis of 3-deoxy-D-manno-octulosonate, part of the oligosaccharide core of lipopolysaccharide.

Species distribution

Gene table