InterPro domain: IPR006261

This entry represents a group of dNTP triphosphohydrolases, which is an class of enzymes capable of hydrolyzing deoxynucleoside 5'-triphosphates (dNTPs) into the corresponding deoxynucleosides and tripolyphosphate (PPPi) [ 1 ]. They can be classified into three subgroups [ 2 ]:

• Type 1: represented by E. coli dGTPase and Q9I4L1 , which preferentially hydrolyzes dGTP without an activator [ 3 ].
• Type 2: represented by Q5SL81 , which hydrolyzes multiple kinds of dNTP upon activation by binding of an activator [ 3 ].
• Type 3: represented by Q9HZG5 , which hydrolyzesmultiple kinds of dNTP without an activator [ 4 ].

1. Structure of Escherichia coli dGTP triphosphohydrolase: a hexameric enzyme with DNA effector molecules. J. Biol. Chem. 290, 10418-29
2. Two dNTP triphosphohydrolases from Pseudomonas aeruginosa possess diverse substrate specificities. FEBS J. 276, 3211-21
3. Biochemical characterization of TT1383 from Thermus thermophilus identifies a novel dNTP triphosphohydrolase activity stimulated by dATP and dTTP. J. Biochem. 136, 221-31