InterPro domain: IPR006257

General Information

  • Identifier IPR006257
  • Description Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

Abstract

The pyruvate dehydrogenase complex catalyses the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) [ 1 ]. This entry represent the dihydrolipoamide acetyltransferase (E2) subunit ( 2.3.1.12 ), also known as Lat1.


1. Sequence similarities within the family of dihydrolipoamide acyltransferases and discovery of a previously unidentified fungal enzyme. Biochim. Biophys. Acta 1076, 225-32

Species distribution

Gene table