InterPro domain: IPR006240
General Information
- Identifier IPR006240
- Description 3'(2'),5'-bisphosphate nucleotidase CysQ
- Number of genes 1
- Gene duplication stats Loading...
- Associated GO terms GO:0000287 GO:0008441 GO:0006790
Abstract
This entry represents CysQ, a 3'-nucleotidase that converts adenosine-3',5'-bisphosphate (PAP) to AMP [ 1 ]. It may also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) [ 2 ]. CysQ contains a conserved sequence motif, D(X)n EE(X)nDP(I/L)D(S/G/A)T(X)nWD(X)11GG, required for metal ion coordination. It has been found to be inhibited by lithium and calcium in vitro and is a main target of lithium toxicity in vivo [ 3 ].
1. Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells. Nucleic Acids Res. 34, 2364-73
2. A rice HAL2-like gene encodes a Ca(2+)-sensitive 3'(2'),5'-diphosphonucleoside 3'(2')-phosphohydrolase and complements yeast met22 and Escherichia coli cysQ mutations. J. Biol. Chem. 270, 29105-10