InterPro domain: IPR006204
General Information
- Identifier IPR006204
- Description GHMP kinase N-terminal domain
- Number of genes 1318
- Gene duplication stats Loading...
- Associated GO terms GO:0005524
Abstract
The galacto- ( 2.7.1.6 ), homoserine ( 2.7.1.39 ), mevalonate ( 2.7.1.36 ) and phosphomevalonate ( 2.7.4.2 ) kinases contain, in their N-terminal section, a conserved domain with a Gly/Ser-rich region which is probably involved in the binding of ATP [ 1 , 2 ]. This group of kinases has been called 'GHMP' (from the first letter of their substrates).
This domain is also found in diphosphomevalonate decarboxylases, which are structurally related members of the GHMP superfamily [ 3 ], but do not possess kinase activity.
1. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Mol. Cell. Biol. 11, 620-31
2. Identification of the gene encoding homoserine kinase from Arabidopsis thaliana and characterization of the recombinant enzyme derived from the gene. Arch. Biochem. Biophys. 372, 135-42
3. Crystal structures of Trypanosoma brucei and Staphylococcus aureus mevalonate diphosphate decarboxylase inform on the determinants of specificity and reactivity. J. Mol. Biol. 371, 540-53