InterPro domain: IPR006124
General Information
- Identifier IPR006124
- Description Metalloenzyme
- Number of genes 361
- Gene duplication stats Loading...
- Associated GO terms GO:0003824 GO:0046872
Abstract
This domain unites alkaline phosphatase, N-acetylgalactosamine-4-sulphatase, and cerebroside sulphatase, enzymes with known three-dimensional structures, with phosphopentomutase, 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, phosphoglycerol transferase, phosphonate monoesterase, streptomycin-6-phosphate phosphatase, alkaline phosphodiesterase/nucleotide pyrophosphatase PC-1, and several closely related sulphatases. This domain is also related to alkaline phosphatase IPR001952 [ 1 ].The most conserved residues areprobably involved in metal binding and catalysis.
1. A superfamily of metalloenzymes unifies phosphopentomutase and cofactor-independent phosphoglycerate mutase with alkaline phosphatases and sulfatases. Protein Sci. 7, 1829-35