InterPro domain: IPR006086

This entry represents a domain found on Xeroderma Pigmentosum Complementation Group G (XPG) protein [ 1 ]. XPG is a DNA endonuclease involved in DNA excision repair [ 2 ]. The internal XPG (XPG-I) domain contains many cysteine and glutamate amino acid residues that are frequently found in various enzyme active sites of DNA nucleases. The I domain, together with the N-terminal, forms the catalytic domain that contains the active site [ 3 ].

1. Isolation of active recombinant XPG protein, a human DNA repair endonuclease. J. Biol. Chem. 269, 15965-8
2. Human xeroderma pigmentosum group G gene encodes a DNA endonuclease. Nucleic Acids Res. 22, 3312-6
3. The XPG story. Biochimie 85, 1113-21