InterPro domain: IPR006076
General Information
- Identifier IPR006076
- Description FAD dependent oxidoreductase
- Number of genes 1002
- Gene duplication stats Loading...
- Associated GO terms GO:0016491
Abstract
This entry includes various FAD dependent oxidoreductases: glycerol-3-phosphate dehydrogenase ( 1.1.99.5 ), sarcosine oxidase beta subunit ( 1.5.3.1 ), D-amino acid dehydrogenase ( 1.4.99.1 ), D-aspartate oxidase ( 1.4.3.1 ).
D-amino acid oxidase ( 1.4.3.3 ) (DAMOX or DAO) is an FAD flavoenzyme that catalyzes the oxidation of neutral and basic D-amino acids into their corresponding keto acids. DAOs have been characterised and sequenced in fungi and vertebrates where they are known to be located in the peroxisomes. D-aspartate oxidase ( 1.4.3.1 ) (DASOX) [ 1 ] is an enzyme, structurally related to DAO, which catalyzes the same reaction but is active only toward dicarboxylic D-amino acids. In DAO, a conserved histidine has been shown [ 2 ] to be important for the enzyme's catalytic activity.
1. The primary structure of the flavoprotein D-aspartate oxidase from beef kidney. J. Biol. Chem. 267, 11865-71
2. Studies on Phe-228 and Leu-307 recombinant mutants of porcine kidney D-amino acid oxidase: expression, purification, and characterization. J. Biochem. 109, 171-7