InterPro domain: IPR006075

General Information

  • Identifier IPR006075
  • Description Aspartyl/Glutamyl-tRNA(Gln) amidotransferase, subunit B/E, catalytic
  • Number of genes 148
  • Gene duplication stats Loading...
  • Associated GO terms GO:0016874  

Abstract

Glutamyl-tRNA(Gln) amidotransferase subunit B ( 6.3.5 ) [ 1 ] is a microbial enzyme that furnishes a means for formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The enzyme is composed of three subunits: A (an amidase), B and C. It also exists in eukaryotes as a protein targeted to the mitochondria.


1. Glu-tRNAGln amidotransferase: a novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation. Proc. Natl. Acad. Sci. U.S.A. 94, 11819-26

Species distribution

Gene table

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