InterPro domain: IPR006070

General Information

  • Identifier IPR006070
  • Description YrdC-like domain
  • Number of genes 265
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003725  

Abstract

This domain has been shown to bind preferentially to dsRNA [ 1 ]. This domain is found in Sua5 ( P32579 ) as well as YrdC ( SP45748 ) and carbamoyltransferase HypF. The YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA [ 2 ]. Sua5 has been shown to be required for translational regulation [ 3 ] and telomere recombination in yeast [ 4 ].


1. The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. Protein Sci. 9, 2557-66
2. The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. Nucleic Acids Res. 37, 2894-909
3. The Sua5 protein is essential for normal translational regulation in yeast. Mol. Cell. Biol. 30, 354-63
4. Sua5p is required for telomere recombination in Saccharomyces cerevisiae. Cell Res. 20, 495-8

Species distribution

Gene table