InterPro domain: IPR005999

General Information

  • Identifier IPR005999
  • Description Glycerol kinase
  • Number of genes 136
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006072   GO:0004370  

Abstract

Glycerol kinase ( 2.7.1.30 ) is a bacterial sugar kinase which catalyzes the Mg-ATP-dependent phosphorylation of glycerol to yield glycerol 3-phosphate. The enzyme from Escherichia coli is an allosteric regulatory enzyme whose activity is inhibited by fructose 1,6-bisphosphate (FBP) and the glucose-specific phosphocarrier of the phosphoenolpyruvate:glycose phosphotransferase system, IIA(Glc), structural studies suggest a nucleophilic in-line transfer mechanism for the ATP-dependent phosphorylation of glycerol by glycerol kinase [ 1 ].


1. X-Ray structure of glycerol kinase complexed with an ATP analog implies a novel mechanism for the ATP-dependent glycerol phosphorylation by glycerol kinase. Biochem. Biophys. Res. Commun. 259, 640-4

Species distribution

Gene table