InterPro domain: IPR005990

General Information

  • Identifier IPR005990
  • Description Inosine-5'-monophosphate dehydrogenase
  • Number of genes 206
  • Gene duplication stats Loading...
  • Associated GO terms GO:0006164   GO:0003938  

Abstract

This entry includes inosine-5'-monophosphate dehydrogenases and guanosine 5'-monophosphate (GMP) reductase. Inosine-5'-monophosphate dehydrogenase catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth [ 1 , 2 ]. GMP catalyses the irreversible NADPH-dependent deamination of GMP to IMP [ 3 ].


1. IMP dehydrogenase from Pneumocystis carinii as a potential drug target. Antimicrob. Agents Chemother. 41, 40-8
2. Differential splicing of Pneumocystis carinii f. sp. carinii inosine 5'-monophosphate dehydrogenase pre-mRNA. Gene 263, 151-8
3. Guanosine 5'-monophosphate reductase from Leishmania donovani. A possible chemotherapeutic target. Biochem. Pharmacol. 31, 3891-7

Species distribution

Gene table