InterPro domain: IPR005861

The histidinol phosphate aminotransferase family consists of class I pyridoxal-5'-phosphate (PLP)-dependent enzymes that catalyze a step of L-histidinebiosynthesis [ 1 ]. These proteins are highly specific enzymes inthe sense that no other aminotransferases are known to becapable of utilizing imidazoleacetol phosphate, with deletions leading to auxotrophy. A subgroup of these enzymes have broader substrate specificity and are capable of using aromatic amino acid substrates in vitro and in vivo

1. Evolutionary recruitment of biochemically specialized subdivisions of Family I within the protein superfamily of aminotransferases. J. Bacteriol. 178, 2161-71