InterPro domain: IPR005793
General Information
- Identifier IPR005793
- Description Formyl transferase, C-terminal
- Number of genes 112
- Gene duplication stats Loading...
- Associated GO terms GO:0009058 GO:0016742
Abstract
Methionyl-tRNA formyltransferase ( 2.1.2.9 ) transfers a formyl group onto the amino terminus of the acyl moiety of the methionyl aminoacyl-tRNA. The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and by impairing its binding to EFTU-GTP. This family also includes formyltetrahydrofolate dehydrogenases, which produce formate from formyl-tetrahydrofolate. These enzymes contain an N-terminal domain in common with other formyl transferase enzymes ( IPR002376 ). The C-terminal domain has an open beta-barrel fold [ 1 ].
1. Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase. EMBO J. 15, 4749-58