InterPro domain: IPR005792

This family represents eukaryotic protein disulphide isomerases retained in the endoplasmic reticulum (ER) and other closely related forms [ 1 ]. Some members have been assigned alternative or additional functions such as prolyl 4-hydroxylase [ 2 , 3 ]. Members of this family have at least two protein-disulphide domains, each similar to thioredoxin but with the redox-active disulphide in the motif PWCGHCK, and an ER retention signal at the extreme C terminus (KDEL, HDEL, and similar motifs).

1. Proteins of the PDI family: unpredicted non-ER locations and functions. J. Cell. Physiol. 193, 154-63
2. Characterization of the human gene for a polypeptide that acts both as the beta subunit of prolyl 4-hydroxylase and as protein disulfide isomerase. J. Biol. Chem. 263, 16218-24
3. Protein disulfide isomerase: the multifunctional redox chaperone of the endoplasmic reticulum. Semin. Cell Dev. Biol. 10, 481-93