InterPro domain: IPR005720

Dihydroorotate dehydrogenase ( 1.3.3.1 ) (DHOdehase) catalyses the fourth step in the de novo biosynthesis of pyrimidine, the conversion of dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein. In bacteria (gene pyrD), DHOdease is located on the inner side of the cytosolic membrane. In some yeasts, such as in Saccharomyces cerevisiae (gene URA1, subfamily 2), it is a cytosolic protein while in other eukaryotes it is found in the mitochondria [ 1 ].

This entry represents a domain found in the type I dihydroorotate dehydrogenases and dihydropyrimidine dehydrogenase.

1. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Proc. Natl. Acad. Sci. U.S.A. 89, 8966-70