InterPro domain: IPR005679

Ribosomal protein S12 is located at the interface of the large and small ribosomal subunits, where it plays an important role in both tRNA and ribosomal subunit interactions. S12 is essential for maintenance of a pretranslocation state and, together with S13, functions as a control element for the rRNA- and tRNA-driven movements of translocation [ 1 ]. Antibiotics such as streptomycin bind S12 and cause the ribosome to misread the genetic code [ 2 , 3 , 4 ].

This family consists of ribosomal protein S12 from bacteria, mitochondria, and chloroplasts.

1. Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Mol. Cell 12, 321-8
2. Severity of the streptomycin resistance and streptomycin dependence phenotypes of ribosomal protein S12 of Thermus thermophilus depends on the identity of highly conserved amino acid residues. J. Bacteriol. 187, 3548-50
3. Streptomycin revisited: molecular action in the microbial cell. Med. Hypotheses 58, 34-46
4. Streptomycin-resistant and streptomycin-dependent mutants of the extreme thermophile Thermus thermophilus. J. Mol. Biol. 309, 333-8