InterPro domain: IPR005595
General Information
- Identifier IPR005595
- Description Translocon-associated protein (TRAP), alpha subunit
- Number of genes 200
- Gene duplication stats Loading...
- Associated GO terms GO:0005789
Abstract
The alpha-subunit of the TRAP (translocon-associated protein) complex is a single-spanning membrane protein of the endoplasmic reticulum (ER) [ 1 ]. The four-subunit (alpha, beta, gamma and delta) TRAP complex localises in the ER membrane and associates with the Sec61 translocon as a heterotetramer [ 2 ]. It also interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins [ 3 ]. TRAP complex may also be involved in endoplasmic reticulum-associated degradation [ 4 ].
1. The N-terminal region of the alpha-subunit of the TRAP complex has a conserved cluster of negative charges. FEBS Lett. 349, 324-6
2. Architecture of the ribosome-channel complex derived from native membranes. J. Mol. Biol. 348, 445-57
3. Palmitoylated calnexin is a key component of the ribosome-translocon complex. EMBO J. 31, 1823-35
4. Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation. EMBO Rep. 8, 483-9