InterPro domain: IPR005579

Cgr1 is involved in nucleolar integrity and is required for processing pre-rRNA for the 60S ribosome subunit. In Saccharomyces cerevisiae, this protein is conserved and contributes to compartmentalisation of nucleolar constituents [ 1 ]. Cgr1 is a small hydrophilic protein and members of this family are coiled-coil proteins [ 2 ]. Its primary role appears to be in ribosome biogenesis [ 2 , 3 ]. Expression of CGR1 is also associated with a cessation of yeast cell growth, which is a prerequisite for germination in this organism [ 4 ].

1. Identification of a role for Saccharomyces cerevisiae Cgr1p in pre-rRNA processing and 60S ribosome subunit synthesis. Microbiology (Reading, Engl.) 148, 1081-90
2. Cgr1p, a novel nucleolar protein encoded by Saccharomyces cerevisiae orf YGL0292w. Curr. Microbiol. 42, 65-9
3. Isolation and expression of a gene (CGR1) regulated during the yeast-hyphal transition in Candida albicans. Biochim. Biophys. Acta 1517, 288-92