InterPro domain: IPR005576

Rpb7 is a subunit of eukaryotic RNA polymerase (RNAP) II that is homologous to Rpa43 of RNAP I, Rpc8/Rpc25 of RNP III, and RpoE of archaeal RNAP. Rpb7 binds to Rpb4 to form a heterodimer. This complex is thought to interact with the nascent RNA strand during RNA polymerase II elongation [ 1 ] and plays a part in transcription, mRNA transport and DNA repair [ 2 ]. In RNA polymerase I, Rpa43 is at least one of the subunits contacted by the transcription factor TIF-IA [ 3 ]. The N terminus of Rpb7 and homologues has a SHS2 domain that is involved in protein-protein interaction [ 4 ].

1. Structure of an archaeal homolog of the eukaryotic RNA polymerase II RPB4/RPB7 complex. Mol. Cell 8, 1137-43
2. Rpb4 and Rpb7: subunits of RNA polymerase II and beyond. Trends Biochem. Sci. 29, 674-81
3. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. EMBO Rep. 3, 1082-7
4. The SHS2 module is a common structural theme in functionally diverse protein groups, like Rpb7p, FtsA, GyrI, and MTH1598/TM1083 superfamilies. Proteins 56, 795-807