InterPro domain: IPR005481

This domain is structurally related to the PreATP-grasp domain. It is found at the N terminus of biotin carboxylase enzymes [ 1 , 2 , 3 ], and propionyl-CoA carboxylase A chain [ 4 ].

1. Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase. Biochemistry 33, 10249-56
2. Structural impact of human and Escherichia coli biotin carboxyl carrier proteins on biotin attachment. Biochemistry 49, 4687-94
3. Structural evidence for substrate-induced synergism and half-sites reactivity in biotin carboxylase. Protein Sci. 17, 1706-18
4. Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature 518, 120-4