InterPro domain: IPR005366
General Information
- Identifier IPR005366
- Description ER membrane protein complex subunit 8/9
- Number of genes 153
- Gene duplication stats Loading...
- Associated GO terms GO:0072546
Abstract
Saccharomyces cerevisiae ER membrane protein complex (EMC) comprises six subunits [ 1 ]. Four and three additional subunits have been identified in mammals and Drosophila, respectively [ 2 ]. EMC is required for protein folding in the endoplasmic reticulum (ER). It also facilitates lipid transfer from ER to mitochondria [ 3 ].
This family includes mammalian subunits EMC8 and EMC9, and Drosophila EMC8/9 homologue [ 4 ]. EMC8 is also known as neighbour of COX4 (NOC4) [ 5 ].
1. Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323, 1693-7
2. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105
3. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. PLoS Biol. 12, e1001969
4. dPob/EMC is essential for biosynthesis of rhodopsin and other multi-pass membrane proteins in Drosophila photoreceptors. Elife 4
5. The 5' region of the COX4 gene contains a novel overlapping gene, NOC4. Mamm. Genome 10, 506-12