InterPro domain: IPR005352

This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In Saccharomyces cerevisiae (Baker's yeast) they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins [ 1 ]. The family contains a conserved arginine and histidine that may be functionally important.

1. A novel gene conserved from yeast to humans is involved in sterol biosynthesis. J. Lipid Res. 42, 150-4