InterPro domain: IPR005349
General Information
- Identifier IPR005349
- Description TMEM14 family
- Number of genes 686
- Gene duplication stats Loading...
- Associated GO terms GO:0016020
Abstract
This entry includes a group of transmembrane proteins, including protein FATTY ACID EXPORT 1 (FAX1) from Arabidopsis and TMEM14 from animals. FAX1 mediates the export of free fatty acid from the plastids and is required for biogenesis of the outer pollen cell wall, in particular for the assembly of exine and pollen coat and for the release of ketone wax components [ 1 ]. The Zebrafish TMEM14 is required for normal heme biosynthesis [ 2 ]. The structure of human TMEM14 showed a three helical bundle [ 3 ].
1. FAX1, a novel membrane protein mediating plastid fatty acid export. PLoS Biol. 13, e1002053
2. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab. 10, 119-30
3. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. Nat. Methods 9, 834-9