InterPro domain: IPR005256

This enzyme resembles some other chorismate-binding enzymes, including para-aminobenzoate synthase (pabB) and isochorismate synthase. There is a fairly deep split between two sets, seen in the pattern of gaps as well as in amino acid sequence differences. This group includes eukaryotes, archaea, and many bacterial lineages; sequences from the second group may resemble pabB more closely than other trpE from the other group. The other group includes Gram-negative proteobacteria such as Escherichia coli and Helicobacter pylori but also the Gram-positive organism Corynebacterium glutamicum, and is described by IPR005257 .

A sequence from Bacillus subtilis that scores above the trusted cut-off is annotated as PabB rather than TrpE. However, it is part of an operon that is required for Trp as well as folate biosynthesis, is Trp-repressible, and contains TrpG. It is likely that this sequence annotated as PabB functions both as PabB and as TrpE.