InterPro domain: IPR005225
General Information
- Identifier IPR005225
- Description Small GTP-binding protein domain
- Number of genes 12976
- Gene duplication stats Loading...
- Associated GO terms GO:0005525
Abstract
Proteins with a small GTP-binding domain include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors [ 1 ], tdhF, and many others [ 2 ]. In some proteins the domain occurs more than once. Among them there is a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model.
1. The small G proteins of the Arf family and their regulators. Annu. Rev. Cell Dev. Biol. 23, 579-611
2. Structure of small G proteins and their regulators. Acta Biochim. Pol. 48, 829-50