InterPro domain: IPR005152

This entry represents a family of secreted lipases. Family members include the LIP lipases from Candida albicans, which are expressed and secreted during the infection cycle of these pathogens [ 1 ].

This entry also includes trichothecene C-3 esterase (also known as Tri8) from Fusarium sporotrichioides. It is part of the core gene cluster that mediates the biosynthesis of trichothecenes, a very large family of chemically related bicyclic sesquiterpene compounds acting as mycotoxins, including T2-toxin [ 2 , 3 ]. Also included in this family is lactone esterase (also known as lipase-like enzyme SBLE), which is responsible for the lactonization of acidic sophorolipids [ 4 ].

1. Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Arch. Microbiol. 174, 362-74
2. A genetic and biochemical approach to study trichothecene diversity in Fusarium sporotrichioides and Fusarium graminearum. Fungal Genet. Biol. 32, 121-33
3. Fusarium Tri8 encodes a trichothecene C-3 esterase. Appl. Environ. Microbiol. 68, 2959-64
4. Characterization of a novel enzyme-Starmerella bombicola lactone esterase (SBLE)-responsible for sophorolipid lactonization. Appl. Microbiol. Biotechnol. 100, 9529-9541