InterPro domain: IPR005145
General Information
- Identifier IPR005145
- Description Threonylcarbamoyl-AMP synthase, C-terminal domain
- Number of genes 2
- Gene duplication stats Loading...
Abstract
This domain can be found in the C terminus of threonylcarbamoyl-AMP synthases, including Sua5 from Saccharomyces cerevisiae and YwlC from Bacillus subtilis. Threonylcarbamoyl-AMP synthase is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine [ 1 , 2 ].
This domain adopts the Rossmann fold and may be involved in GTP and/or tRNA binding based on structural similarity with both GTP and tRNA binding proteins [ 3 ].
1. The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. Nucleic Acids Res. 37, 2894-909
2. Mechanism of N6-Threonylcarbamoyladenonsine (t(6)A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl-AMP. Biochemistry 51, 8950-63
3. X-ray crystal structure of a hypothetical Sua5 protein from Sulfolobus tokodaii strain 7. Proteins 70, 1108-11