InterPro domain: IPR005135

General Information

  • Identifier IPR005135
  • Description Endonuclease/exonuclease/phosphatase
  • Number of genes 3852
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003824  

Abstract

This domain is found in a large number of proteins including magnesium dependent endonucleases and phosphatases involved in intracellular signalling [ 1 ]. Proteins this domain is found in include: AP endonuclease proteins ( 4.2.99.18 ), DNase I proteins ( 3.1.21.1 ), Synaptojanin an inositol-1,4,5-trisphosphate phosphatase ( 3.1.3.56 ) and Sphingomyelinase ( 3.1.4.12 ).


1. Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases. Trends Biochem. Sci. 25, 272-3

Species distribution

Gene table