InterPro domain: IPR005108

The HELP (Hydrophobic ELP) domain is found in EMAP and EMAP-like proteins (ELPs) [ 1 , 2 ]. Although called a domain it contains a predicted transmembrane helix and may not form a globular domain. It is also not clear if these proteins localize to membranes.

1. The human EMAP-like protein-70 (ELP70) is a microtubule destabilizer that localizes to the mitotic apparatus. J. Biol. Chem. 277, 1301-9
2. Molecular characterization of the 77-kDa echinoderm microtubule-associated protein. Homology to the beta-transducin family. J. Biol. Chem. 269, 31777-84