InterPro domain: IPR005043
General Information
- Identifier IPR005043
- Description Exportin-2, C-terminal
- Number of genes 178
- Gene duplication stats Loading...
- Associated GO terms GO:0005515 GO:0031267
Abstract
This entry represents the C-terminal domain of XPO2. Structural studies of its yeast homologue, Cse1, indicate that this domain binds to both the transport-orchestrating protein RanGTP and the cargo molecule that is being exported [ 1 ].
Exportin-2, also known as CAS, is an export receptor for importin-alpha [ 2 ]. It binds strongly to importin alpha only in the presence of RanGTP, forming an importin alpha/CAS/RanGTP complex. Exportin-2 mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates have been released into the nucleoplasm [ 3 ].
1. Structural basis for the assembly of a nuclear export complex. Nature 432, 872-7
2. Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor. Cell 90, 1061-71
3. Genetic evidence for interactions between yeast importin alpha (Srp1p) and its nuclear export receptor, Cse1p. Mol. Gen. Genet. 261, 788-95