InterPro domain: IPR004948
General Information
- Identifier IPR004948
- Description Nucleoside-triphosphatase, THEP1 type
- Number of genes 111
- Gene duplication stats Loading...
- Associated GO terms GO:0017111
Abstract
This entry represents a family of nucleoside-triphosphatases which have activity towards ATP, GTP, CTP, TTP and UTP and may hydrolyse nucleoside diphosphates with lower efficiency [ 1 ]. It includes proteins from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase [ 2 ]. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme [ 3 ]. The sequence carries both a Walker A and Walker B motif which together are characteristic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue [ 4 ].
1. NMR structure and functional characterization of a human cancer-related nucleoside triphosphatase. J. Mol. Biol. 367, 788-801
2. Thermophile-specific proteins: the gene product of aq_1292 from Aquifex aeolicus is an NTPase. BMC Biochem. 4, 12
3. Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold. BMC Struct. Biol. 5, 7