InterPro domain: IPR004910

This domain is found in both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins [ 1 ]. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A [ 2 , 3 ]. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus [ 4 ]. This domain includes the CULT domain from proteins such as Cereblon [ 5 ].

1. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. Insect Mol. Biol. 10, 77-86
2. Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1. Dev. Cell 12, 17-30
3. Centromeres poised en pointe: CDKs put a hold on CENP-A assembly. Dev. Cell 22, 1-2
4. Keeping centromeric identity. Nat. Rev. Mol. Cell Biol. 13, 340
5. The thalidomide-binding domain of cereblon defines the CULT domain family and is a new member of the β-tent fold. PLoS Comput. Biol. 11, e1004023