InterPro domain: IPR004882
General Information
- Identifier IPR004882
- Description Luc7-related
- Number of genes 317
- Gene duplication stats Loading...
- Associated GO terms GO:0006376 GO:0003729 GO:0005685
Abstract
This family consists of several Luc7 protein homologues that are restricted to eukaryotes. In budding yeast, Luc7 is an essential subunit of the yeast U1 snRNP, which forms the spliceosomal commitment complex with other proteins that targets pre-mRNA to the splicing pathway [ 1 , 2 ]. Its N-terminal zinc finger has been found to bind pre-mRNA [ 3 ]. This entry also contains human and mouse Luc7 like (LUC7L) proteins [ 3 ].
1. The U1 snRNP-associated factor Luc7p affects 5' splice site selection in yeast and human. Nucleic Acids Res. 35, 5874-85
2. Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain. Genomics 71, 307-14
3. Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev. 13, 2425-38